Read e-book online Anticarbohydrate Antibodies: From Molecular Basis to PDF

By Paul Kosma,Sven Müller-Loennies

ISBN-10: 3709108691

ISBN-13: 9783709108697

ISBN-10: 3709148359

ISBN-13: 9783709148358

Many pathogens and aberrant malignant cells exhibit special carbohydrates on their floor representing beautiful objectives for vaccine layout. massive development has lately been made within the identity of novel carbohydrate established vaccines and a mess has reached scientific section experiences. The luck of numerous approved carbohydrate dependent vaccines opposed to bacterial pathogens similar to Haemophilus influenzae style b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice strength. even if, the research of anti-carbohydrate antibodies is technically tough and partially due to low affinities and promiscuous specificity they've got now not been medically exploited to complete power. The examine of antibody specificities and identity of protecting carbohydrate epitopes lies on the middle of winning vaccine layout. as well as remedy, antibodies regularly function diagnostic instruments in clinical and medical laboratories. during this surroundings excessive affinity and beautiful specificity are vital components for his or her profitable use. “Anticarbohydrate Antibodies – from molecular foundation to medical program” compiles present wisdom at the immunological reputation of carbohydrates by means of the adaptive immune procedure from a molecular viewpoint offering primary perception wanted for advancing clinically proper diagnostics and healing purposes. in response to major growth within the fields of glycoimmunology and structural biology lately, the e-book comprehensively studies the cutting-edge in defining the major parts of carbohydrate popularity by way of antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular good points resulting in particular and comfy binding modes. Backed-up via a mix of recent applied sciences to clarify structural info of carbohydrate-antibody interactions, biomedically vital carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth studies written via famous specialists within the box. primary wisdom of those molecular mechanisms ultimately offers a rational foundation to enhance efficacy of carbohydrate-based vaccines and to additional refine diagnostic instruments in detection of pathogens and malignant cells.

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Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application by Paul Kosma,Sven Müller-Loennies

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